Revisit epithelial-mesenchymal transition to uncover therapeutic vulnerabilities


Jianrong Lu, PhDDepartment of Biochemistry and Molecular BiologyCollege of MedicineUniversity of Florida

“Epithelial-mesenchymal transition (EMT) allows epithelial cancer cells (carcinoma) to acquire mesenchymal cell phenotypes, facilitating tumor metastatic dissemination and therapy resistance. EMT has emerged as a target of prime interest for cancer therapy. However, it remains challenging to eradicate cancer cells that have undergone EMT. We aim to uncover EMT-induced vulnerabilities that may be therapeutically exploited.”