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Integrated Multi-Omics of Myelodysplastic Syndrome

This project (PI: Jinying Zhao) was funded by the University of Florida Office of Research.  The objectives of this pilot study are to generate the first integrative map of 5mC, 5hmC, and gene expression in human bone marrow, and to identify functional epigenetic determinants for myelodysplastic syndrome (MDS).  …

Gut Microbiome, Aging and Cardiometabolic Diseases in American Indians

This project was funded by NIA (R01AG068865, 9/10/2020-8/30/2025, PI: Jinying Zhao). The goal of this project is to identify key gut microbiome features associated with cardiometabolic traits in American Indians in the Strong Heart Study (SHS). We will collect fecal samples from 1500 participants scheduled to visit SHS Phase VII,…

Genome-Wide Mapping and Integrated Analysis of DNA 6mA Methylome in Human AD Brain

This project was funded by NIA (R01AG064786, 9/1/2019-4/30/2024, PI: Jinying Zhao). The objectives of this project are to generate the first detailed map of brain 6mA methylome and identify causative genes harboring aberrant 6mA alterations associated with quantitative neuropathological measures for early features of AD pathology (e.g., amyloid plaques, neurofibrillary…

DNA hydroxymethylation and AD

This project was funded by NIA (7RF1AG052476, 6/15/2016-8/31/2021, PI: Jinying Zhao). The goal of this project is to identify causative 5hmC alterations associated with quantitative neuropathological measures for early features of AD pathology (e.g., amyloid plaques, neurofibrillary tangles). To achieve this, we propose four specific aims: (1)…

Epigenetics Determinants of Major Depression: A Monozygotic Twin Study

This project was funded by NIMH (R01MH097018, 8/15/2013-7/31/2021, PI: Jinying Zhao). The objective of this study is to identify functional epigenetic determinants for major depressive symptoms (MDD). Our central hypothesis is that aberrant DNA methylation and resulting alterations in gene expression are associated with MDD. The rationale…

Telomere Attrition and Diabetes Risk in American Indians

This project was funded by NIDDK (R01DK091369, 9/1/2011-5/31/2016, PI: Jinying Zhao). The objectives of this study are to delineate the prospective impact of telomere attrition on diabetes risk, and to determine genetic, behavioral and psychosocial predictors for accelerated telomere loss. Leukocyte telomere length will be measured by…