This project was funded by NIA (R01AG068865, 9/10/2020-8/30/2025, PI: Jinying Zhao). The goal of this project is to identify key gut microbiome features associated with cardiometabolic traits in American Indians in the Strong Heart Study (SHS). We will collect fecal samples from 1500 participants scheduled to visit SHS Phase VII,…
This project was funded by NIA (R01AG064786, 9/1/2019-4/30/2024, PI: Jinying Zhao). The objectives of this project are to generate the first detailed map of brain 6mA methylome and identify causative genes harboring aberrant 6mA alterations associated with quantitative neuropathological measures for early features of AD pathology (e.g., amyloid plaques, neurofibrillary…
This project was funded by NIA (7RF1AG052476, 6/15/2016-8/31/2021, PI: Jinying Zhao). The goal of this project is to identify causative 5hmC alterations associated with quantitative neuropathological measures for early features of AD pathology (e.g., amyloid plaques, neurofibrillary tangles). To achieve this, we propose four specific aims: (1)…
This project was funded by NIDDK (R01DK107532, 9/15/2016-8/31/2022, PI: Jinying Zhao). The objective of this project is to identify novel and sensitive type 2 diabetes (T2D) predictors that are specific to American Indians beyond classical T2D indicators. To achieve this, we will repeatedly measure concentrations of over…
This project was funded by NIMH (R01MH097018, 8/15/2013-7/31/2021, PI: Jinying Zhao). The objective of this study is to identify functional epigenetic determinants for major depressive symptoms (MDD). Our central hypothesis is that aberrant DNA methylation and resulting alterations in gene expression are associated with MDD. The rationale…
This project was funded by NIDDK (R01DK091369, 9/1/2011-5/31/2016, PI: Jinying Zhao). The objectives of this study are to delineate the prospective impact of telomere attrition on diabetes risk, and to determine genetic, behavioral and psychosocial predictors for accelerated telomere loss. Leukocyte telomere length will be measured by…
